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Kids who beforehand had COVID-19 or the inflammatory situation MIS-C usually are not protected in opposition to the Omicron variant of coronavirus, based on a examine which discovered vaccination, nevertheless, does afford safety. The findings of the examine, revealed not too long ago within the journal Nature Communications, are much like these present in adults.
“I hear mother and father say, ‘Oh, my child had COVID final 12 months,'” mentioned Adrienne Randolph, of Boston Kids’s Hospital, US, senior writer of the analysis paper.
“However we discovered that antibodies produced by prior infections in youngsters do not neutralise Omicron, which means that unvaccinated youngsters stay prone to Omicron,” Randolph mentioned.
The researchers, together with Surender Khurana, from the US Meals and Drug Administration obtained blood samples from 62 youngsters and adolescents hospitalised with extreme COVID-19. Additionally they used information from 65 youngsters and adolescents hospitalised with MIS-C, and 50 outpatients who had recovered from delicate COVID-19. All of the samples had been taken throughout 2020 and early 2021, earlier than the emergence of the Omicron variant.
Within the laboratory, the researchers uncovered the samples to a pseudovirus, and measured how properly antibodies within the samples had been capable of neutralise 5 completely different SARS-CoV-2 variants of concern: Alpha, Beta, Gamma, Delta, and Omicron. A pseudovirus is derived from SARS-CoV-2, however stripped of its virulence. Total, youngsters and adolescents confirmed some lack of antibody cross-neutralisation in opposition to all 5 variants, however the loss was most pronounced for Omicron, the researchers mentioned.
“Omicron may be very completely different from earlier variants, with many mutations on the spike protein, and this work confirms that it is ready to evade the antibody response. Unvaccinated youngsters stay prone,” mentioned Randolph.
In distinction, youngsters who had acquired two doses of COVID-19 vaccine confirmed greater neutralising antibody titers in opposition to the 5 variants, together with Omicron. The researchers hope these findings will encourage mother and father to have their youngsters and teenagers vaccinated.
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